This project was prepared as part of a BioQUEST faculty development workshop entitled Modeling in Bioinformatics at Lane Community College in October 2004. The BioQUEST Curriculum Consortium is committed to the reform of undergraduate biology instruction through an emphasis on engaging students in realistic scientific practices. This approach is sometimes characterized as an inquiry driven approach and is captured in BioQUEST's three P's (problem-posing, problem-solving, and peer-persuasion). As part of this workshop groups of faculty were encouraged to initiate innovative curricular projects. We are sharing these works in progress in the hope that they will stimulate further exploration, collaboration and development. Please see the following links for additional information:

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Protein Structure of Snake Venom: A Phylogenetic Study
 
 
Authors          Audiences          Overview           Materials          Resources           Future Directions
 

 


Authors


Patricia Ashby
Scottsdale Community College


Jim Levenick
Willamette University


Ruth Phillips
Washington State University-Vancouver


Joseph Russin
Lane Community College

 
   
 


Possible Audiences:

BEDROCK Eugene workshop participants  

 
 


Brief Overview:

Venomous snakes generally possess 2 classes of toxins: hemolytic/proteolytic, and neurotoxins. This project investigated one particular hemolytic toxin, Atrolysin C. Our goals were twofold: to establish phylogenetic relationships based on amino acid sequences among various species and attempt to correlate the degree of toxicity with a particular version of the protein.  

 
   
 


Project Materials:

GenBank, NCBI  

 
 


Future Directions:

We'd like to explore the relationship between toxin structure and the ability of certain mammals and snakes to neutralize the toxin.