Opening Activity Data
Globin Gene Server
http://globin.cse.psu.edu/
A database of sequences alignments and experimental results fro the beta-like gene cluster of mammals.
This site provides data and tools for studying the function of DNA sequences, with an emphasis on those involved in the production of hemoglobin. It includes information about naturally-occurring human hemoglobin mutations and their effects, experimental data related to the regulation of the beta-like globin gene cluster, and software tools for comparing sequences with one another to discover regions that are likely to play significant roles.
See the following for more info:
Globin PowerPoint by Sam Donovan
http://globin.cse.psu.edu/html/sample-align.html
http://globin.cse.psu.edu/html/conserved/index.html
set of tools for finding conserved regions in alignments
http://globin.cse.psu.edu/html/dna-sequences.html
Molecule of the month at PDB
Hemoglobin
http://www.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb41_1.html
Myoglobin
http://www.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb1_1.html
Globin Gene Labs
http://www.muhlenberg.edu/depts/biology/courses/bio152/BioinformaticsLab/index.html
SUPERFAMILY globin
http://pir.georgetown.edu/ (Search for Globin)
References
Bashford, D., Chothia, C., and Lesk, A. M. (1987). Determinants of a protein fold: Unique features of the globin bamino acid sequences. J. Mol. Biol., 196:199-216.
Hardison, Ross. Hemoglobins from Bacteria to Man: Evolution of
Different Patterns of Gene Expression.
http://jeb.biologists.org/cgi/reprint/201/8/1099
Hemoglobin_A2_Origin_Evolution_Aftermath.pdf
Porphyrin_Rings.pdf
The_Evolution_of_Hemoglobin.pdf
